I have been on Desogen for almost a year, and I have not really had any problems with it. I had some side effects for the first two months or so (headaches, nausea, crankiness), but they went away. I am taking it because hormonally is a higher midrange pill. I am overweight, and bcps are slightly less effective, especially if you are taking a low dose pill. All bcps have a risk of blood clots, and as was said before, you need to know the signs for any pill.