Luvox, Flexeril, Provigil, Indomethacin

[ctrl-alt-del]

Someone please help me with these four drugs (the reason for the low doses is because I'm sensitive to medication):

Luvox is for depression - 25mg dose is to be taken at bedtime (just started this the other day)

Flexeril is for muscle relaxation/spasms - one 10mg pill taken whenever needed for spasms, usually at bedtime, in order to relax my stiff back due to ongoing low back problems (only use this when I feel really stiff)

Provigil is for wakefulness promoting - 50mg dose is to be taken in the morning in order to fight daytime sleepiness, SSRI-induced drowsiness, and chronic fatigue due to low back pain (haven't used this yet, not sure if it will interact with anything)

Indomethacin is an NSAID for my low back - 25mg dose is to be taken three times a day after food, however, I found that only two times a day takes a lot of the pain away (have been using this for a couple weeks now, but heard somewhere that SSRIs can increase the chances of internal bleeding from NSAIDs - can someone explain that to me?)


I have not started the Provigil yet, and I want to be 200% sure that none of the other three existing meds will have any interactions with it. Thanks for your help.

Please answer ASAP

[ctrl-alt-del]

Anyone? I would like to take Luvox and Indocin (indomethacin) off that list, but I still need help with these two:

- Flexeril (cyclobenzaprine)
- Provigil (modafinil)

After reading this forum for a while, I found which site people use to check interactions and it returned the following interaction between those two (but I still don't have a clue what that means to me):


Moderate Drug-Drug Interaction: cyclobenzaprine (cyclobenzaprine) and modafinil (modafinil)

Coadministration with modafinil may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. Modafinil is a modest inducer of CYP450 3A4 in vitro, and pharmacokinetic studies suggest that its effects may be primarily intestinal rather than hepatic. Thus, clinically significant interactions would most likely be expected with drugs that have low oral bioavailability due to significant intestinal CYP450 3A4-mediated first-pass metabolism (e.g., buspirone, cyclosporine, felodipine, lovastatin, midazolam, nifedipine, nisoldipine, saquinavir, simvastatin, sirolimus, tacrolimus, triazolam, verapamil). However, the potential for interaction should be considered with any drug metabolized by CYP450 3A4, especially given the high degree of interpatient variability with respect to CYP450-mediated metabolism. Pharmacologic response to these drugs may be altered and should be monitored more closely whenever modafinil is added to or withdrawn from therapy. Dosage adjustments may be required if an interaction is suspected.


Help please!

[hessie28]

Last year I was on 1000mg of Provigil. I also took alot of other meds. Never had an interaction. Only thing you should be careful with the Provigil is stuff like Sudafed. I think because of blood pressure. Always check anything before you take anyway.