My personal experience is hell, I began taking this medication for diagnoised fibromyalgia. The issue became that the effectiveness wore off and the Dr's and myself increased the dose. I was not smart enough to know that you should not quit cold turkey, I did so and after managing to get through the first four and a half days went to the Dr because I could not take the withdrawals anymore; no sleep, pain, sweats, chills and affects to my breathing and a runny nose. However because I had already been off the medication my Dr would not start it again, gave me some effexor and said it shouldn't last much longer, that was that. However today the 8th day off the medication I could not take it any longer, I went to the ER because the bodyaches, sweats ect.. had still not subsided and my head hurt like hell. The ER Dr he did not really believe that ultram should have such withdrawl symptoms and thought that there should be another reason for my sysmptoms, he examined me, ruled out some things and concluded that it is possible, He gave me a morphine shot, some additional pain meds which I am afraid to take and clonidine. The Nurse however did a little research and said that I could find some additional info on the Web and what I was experiencing was described by others. In short - DO NOT START Ultram, I have never been addicited to anything else ever and would not have started this battle, I am hoping the withdrawals will stop soon and I will still be sain. Best wishes.