I took tetracycline for about 1 year and not only did it not help with my acne, but it mostly made me sick to my stomach. I do not recall having depression with it, but I have heard that some Rx's will do that. You should talk to your Dr before continuing the RX. Make it a priority...it could be something else altogether, but at least find out if it is your med. If not, then do not feel bad about seeking alternate professional help. Your life can be great!