I just went off Prevacid 2x/day (been on it several years) to Nexium. The change coming off the Prevacid was torture. I had major reflux symptoms that I had never experienced before and was really sick for the first couple weeks. After a month, I still have symptoms I didn't have on the Prevacid. At this point, I don't know if my symptoms are as a result of the Nexium or the acid.
Before on Prevacid: felt no symptoms, but tests showed acid coming up was flaring up my asthma. Symptoms of reflux before Prevacid for me were a chronic cough and belching.
On Nexium: MAJOR heartburn, belching, nausea, diarrhea, coughing, and asthma attacks. It has gotten better over the past month, but symptoms are still present.
I can't imagine what I would be feeling like going off the PPI's all together.