Since I've been off medication now for over 5 years, none of these newer drugs were introduced to me. After the initial 8 months for the plaquenil, I was totally pain free while on the drug. Not every drug is for every person and my rheumy said that it was a trial and error procedure to see what works. I think if I started to show symptoms again, I would ask for the plaquenil...of course he might have newer ideas by now, but knowing how well this worked for me, I would rather give it another chance if I needed something.