She may be overusing her meds, which can cause them to be ineffective. Combivent actually contains albuterol, so she's really double dosing on that. Sometimes when albuterol becomes ineffective Xopenex (levalbuterol) may help,it's more potent but it's EXPENSIVE! There is also Serevent-12 hour duration, with stronger anti-inflammatory effect,but she'd still need a rescue inhaler, because Serevent takes a long time to kick in.Does she take any steroids(like prednisone)-that may also help. Even a leisurely stroll can help weight, along with watching calorie intake. This may not work for your mom, but it may be worth a try.