Yes!
About 5 years ago my manager casually handed me a couple of her vitamins when I mentioned an oncoming cold. I felt "high" within about 30 minutes and for the next 2ish hours.
Now, under a naturopath's care, I take ~20 different supplements and vitamins a day--a total of ~50-60 capsules. Out of what I tried, I cannot take GABA without experiencing dreams so intense I find it difficult getting up in the morning nor Armor Thyroid without experiencing palpitations--in fact, I simply don't take those two, since they defeat the whole purpose of my following a regimine to health.