hi monkey5,
i'm like alex...was diagnosed with major depression and anxiety/panic. no longer have panic, thank God,--guess bec. of the meds i was prescribed, effexor and klonopin. however, after ten years or so, the effexor no longer works. it's really been a struggle for me for the past two years, more than anything, especially in the "dark months"--the winter months. i've tried other meds in conjunction with the effexor (lithium, neurontin, and the pdoc even wanted to put me on levoxyl--the thyroid med., which was supposed to boost my energy levels a bit), however, i didn't take it, although i filled the prescription. i figured as long as my thyroid is normal, why mess with it...because who knows what long-term effects it might have, and honestly speaking, i'm just so freakin' tired of being on so many chemicals, you know?!!! so, i'm no longer on so many, only on effexor, which i'm weaning off of (with my dr's. monitoring), and on klonopin, for anxiety. planning to go on prozac next. it's a costant trial, a constant battle.
i'm also planning to see another dr. whom i heard is a tremendous diagnostician, and i've heard laudable things about her. she's been in the news and has written books and stuff...i'm lucky that she's close, here on long island. her name is dr meena ramani. she was very highly recommended to me by someone whom she's helped very much--not only this person, but her daughters as well. hopefully, she may have some new insights into this problem, and may offer a different treatment plan. or maybe, if there're still some shamans left in the world, i'll just go to one of them. i'm sure i can find one if i search really hard...

no disrespect intended.
monkey5, look at the posts/threads written by
pianoman. he's looking into newer and different treatment possibilities. and, he's a funny guy too...you might just get a laugh out of it...i did...
don't lose hope!!!
blessings