Hi, debo3. I took 5-HTP for about a year and a half and it worked really well for my depression and anxiety. It should be taken on an empty stomach, this helps it get better metabolized. Taking a good B-complex vitamin with it will also help with metabolization. I started with 50mg and increased it every two weeks by 50mg. The optimum dose for me was 200mgs, which is a high dose. I took it in the morning. It usually makes people sleepy so they take it at night. I'm an oddball, though, it kept me up if I tried taking it at night.