I've been on spiro for almost a month now, and it's working out just fine. My face is clearing, but I'm not sure if that's from the spiro yet or the topicals. I am, however, getting a blood test done on Tuesday at my doctor's request to check my potassium levels. Also, I don't believe you should be on both Yasmin and spiro at the same time; I think it's one or the other. I am on birth control, but it's something other than Yasmin.