trust me on this.first if you do get breast then all you have to do is stop taking it and you breast will go away.second im on a low dose of estrogen and im not getting huge breast.but then again im willing to change my sex if i had to.i went to a lesbian bar and seen all the cute girls and said hey maybe being a girl aint a bad thing after all.i dont expect any guys to go to these extremes but you gotta realize if severe acne is making your life a living nightmare this might not be a bad alternative.anyway you could take 500 mgs of spiro and 7 mgs of premerin and still not look girl like unless youre under 20 and it might prevent you from developing into a man.if you want to research the effects on spiro on guys then go to the transexual sites on the internet.........not the porn sites.spiro wont make you a transexual but it will clear your skin with at least 100 mgs a day.if you just want a decrease in the acne you have go on 25mgs to 50mgs a day.i dont think your face will totally clear up but you wont get steril either.it might just be enough so you dont get huge cysts and get scarring.my derm has 4 guys on 25 mgs a day.he is located in harrisburg,pa.my md is from a small conservative town in north central pa and she will prescibe me spiro and premerin.dont take premerin because you will start to develope breast over a long period of time.spiro at 100 mgs will NOT turn you into a girl.it does work very good on both guys and girls.try sweet jade diet plan and like 25 to 50 mgs a day of spiro andv take it everyday.this is not a cure unless you render yourself steril then i think your acne problems will be gone forever but so will your sex life.it has to be takin every day also.it has worked a miracle on my whole body.you just have to ask yourself how bad is this bothing you?and if your acne is not severe it might even clear it up totally but i suggest using topicals for mild to moderate acne.accutane and anti-androgens for guys are the last resorts.you could also cycle on and off of spiro....like 4 months on...a month off.....something like that and best you get blood test for your liver.best bet go to a female doc or female endo or derm,they might be more understanding than a male doc.