Hey Scott, I'm not sure of the answer to your question for sure, because I think it may be kinda an individual thing. But, again, not sure. I have found that my tolerance(once titrated properly)has not shot up terribly at all. I think the key here is being titrated to the right level though...does not mean you won't need another bump up at some point but certainly not like you do during titration. So, I guess my answer is, at least for me, I have not had my tolerance increase real fast at all since being on long acting meds. Hope this helps at least a little...Love, Surgical Disaster