Most cat-scratch disease begins with a scratch from the claw or tooth of a kitten younger than six months of age. It can also be caught from an adult cat. Most cases of cat-scratch disease occur in children between the ages of 2 and 14, and in veterinarians (those most likely to be scratched by a cat). For reasons yet to be determined, most cases occur in the fall or winter months.
Sometime between 3 and 30 days following the scratch (usually 7 to 12 days), the child breaks out with one or more pimples at the site of the scratch. These last for 1 to 4 weeks, until nearby lymph nodes begin to swell and become tender. Sometimes these will drain pus. Only about a third of kids will feel sick, with a fever, fatigue, decreased appetite, or headache. This is not a serious disease.
Most of the time, the swollen lymph nodes last from 4 to 6 weeks, and then the child recovers fully. Occasionally, the swollen nodes can last for a year. Only rarely have complications been reported, mostly in immunocompromised individuals. Treatment is usually unnecessary, since people recover well on their own, but several antibiotics (such as Zithromax and Biaxin) have been shown to shorten the course of the illness.
Diagnosis is now made by a blood test (or by biopsy, if other more serious conditions are suspected). The skin test is no longer performed, since it is less accurate and has now been shown to pass other known (and perhaps unknown?) diseases.