Since I take a total of 22 pills, tablets and or capsules a day, naturally I am reluctant to start any new medication and very careful when I do. Recently, my primary care physician put me on Vicodin for a week because of some severe pain to my neck that was not responding to therapy. I was assured by her and then the pharmacists, when I asked, that Vicodin would have absolutely no effect on my heart or my blood pressure. I also read the PDR and found no contraindications.