I get sore and enlarged boobs while I am on depo and the two times I have been off it. (my hubby loves it too when they swell, he asks when did you get implants?? It sucks they hurt so bad, especially when I take off my bra-ooooh that hurts, I won't even let him TOUCH them!) I don't know why we go through these hormonal bouts, but I asked my dr and it wasn't anything to worry about. My boobs were swollen and hurting for three months, and I was never pregnant. THis last time, I was on depo. I doubt you will get a straight answer on this, sorry to say. Hope you get some relief soon though!(oh, and mine just shrank and quit hurting this past week

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