I had daily migraines for nearly two years now, but just in the last month my doctor put me on a different migraine preventative. I take Pamelor, and I've actually had some luck with it. I only have about 4 migraines a week now, and am getting progressively better. I know that still doesn't sound too great but for me it's a huge improvement. I tried Topamax and I didn't have much luck. I had really bad side effects and it didn't help at all. I also, tried Effexor and Elavil, but no luck. I felt a little bit better on Depakote, but I had started to have liver dysfunction. You might have some luck on Topamax. I've read quite a few success stories with it. Well, I wish you luck. Just have faith that you'll eventually find something that works for you.