Beta Blockers can worsen asthma by affecting blood flow and vessels in the bronchial tissue, some are worse than others like Inderal is one of the worst, but tenormin, metapropol (sp) are bad but their need outways the possible asthma problem and it's not that bad for some. The exact mechanism that happens with these drugs I don't know and have never found an indepth reason, other than what I wrote. Chronic sinus infections are caused by bacteria that gets trapped in the sinus cavity brought on by allergy, immune exhaustion etc, I had it for years every other month and finally I went to a doctor who ran tests and did a MRI, I have panasinus, brought on by years of self treatment and neglect. I was put on antibiotics for 3 months, and now 5 yrs later I have had only 3 sinus infections of a very mild degree. I still have diseaed sinuses from scar tissue but I would do that antibiotic treatment again in a heart beat after living with that for 30 yrs. Underactive thyroid can have a sign of nasal swelling, seldom sinus infection if taken care of, it's rare but it happens. My thyroid is fine when tested. Sometimes it is a deviated septum, anatomically a problem, genetics, if your parent had it you have a 80% chance of having the problem and so on. The first thing my Dr checked was hormones, then MRI.