Differin can give u a intail breakout since what id does as acts as a Exfoliator gettting the crap plogged dee inside your poes out...it gently sheds the skin..I'm on it now 2 days shy of a week..it has made me skin a tad bit dry and helps smooth it out..i ahvnet hada breakout from it ...it has been working great.. apply Klaron on at nite after applying the differin...i like it alot..Dfferin works best for mild to moderate acne not really bad acne...I use to use Bezamycin too yrs go it alos stopped working aftera while..thats because it has a antibiotic in it(topical) we must get immuned to it..Sulfacet r has worked for my friend...theres azelex,tarozac,duac,spiro,cleocin T....