Hi! Hope your mom is doing well with her treatment. I am going to take Arimidex for five years, and I think that's standard for both drugs. I'm not a doctor, so don't quote me on that. I have a friend who's on Tamoxifen, and she does well on it. I think both drugs (only knowing my story and hers) are similar in side effects: hot flashes, a little fatigue, but generally, life as normal after about a week's worth of adjusting. I got a little nausea for the first week or so, but then I settled in. One thing my oncologist did say was that Arimidex works especially well on microcalicifications on the unaffected side. We'll see, because they just discovered some on me. I'll be curious to find out how well.