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Originally Posted by sgt207
I have been taking zoloft and a PPI since 1999 with only a minimal weight gain of 65 pounds. However, I was told it was not dangerous to take both.
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The same interaction doesn't occur with Zoloft and Nexium.
Plus, it's not "dangerous," but it's something that needs to be watched to make sure everything is being metabolized properly. Most people have no problems at all, but the possibility of a problem is there.