This condition is actually similar to Restless Leg Syndrome. I have it myself and it started when I switched to Methadone for Chronic Pain. I have heard others that have various drugs (Opiate pain meds) that affect them in this way. I believe it is probably (I'm almost positive) that it's the Ultram (Tramadol HCL) and if she switches to something else, it will go away.
One other thing and I feel this is very important. You said she is also on Gabopentin. This is also called Gabitril Filmtabs and it is a medication used for seizures or epilepsy. I was on this at 24 mg a day (taken at bedtime) to help the twitching I have all night. When I refilled it about a month ago, it came with a notice that the FDA has issued a warning that patients taking this medications who DO NOT normally have seizures or epilepsy can in fact begin to have seizures from taking this med. I took it to my doctor and he checked with the head pharmacist at the hospital and then took me off it immediately. Actually, he had me titrate down and then off to avoid having a seizure. I think she needs to talk to her doctor or better yet her pharmacist about taking Gabitril (Gabopentin).
I'm sorry, this was my mistake. I thought it was the generic for Gabitril when it's actually Neurontin. Gabitril is the medication that can cause seizures in people who do not have that condition prior to taking Gabitril. So, if you don't have a condition that causes seizures, do not take Gabitril.