Hey..I was on Bactrim(sulfa drug) for 20 days..immensely helped the acne but I got a crap load of side effects..pounding heart..dizzy..all the lesser side effects..a lot of people don't tolerate sulfa drugs well..check it out on the internet first b/4 u decide to take it..i would rather have pimples than have the side effects I got..and yes u need a prescription