It takes the pill 3-4 weeks to take effect. The first set of pills, you should be using a back-up method. With Lo, if you miss a pill within 3 hours (you normally take it a 7:00 and don't take it until after 10:00) then your chances of getting pregnant dramatically increase. I you take your pills everyday at the same time, then you chances of getting pregnant are low. However, the pill isn't 100%. Even if you take it like you are supposed to, you can still get pregnant.