ASantee,
Everyone here has had very individual responses to the PPIs, but for the most part, they have been somewhat helpful or very helpful. There are also individuals that dont' respond and noone knows why. Possibilites for non-responders include bile reflux and a chromosomal problem that is related to neuropathy and nerve problems.
But - you seem to have classic LPR with the really bad cough and hopefully it will respond to double dosage PPI therapy. Since response is so variable, it's hard to give you a specific timeframe to judge your progress by, but my best estimate is about 30 days. I think that by 30 days you should notice a significant difference.
I had LPR for 6 months without a diagnosis. For 4 of those months, I had been placed on 40 mg of Nexium per day (1 pill) which did nothing, and LPR was never mentioned. I just had a local ENT who noticed "some reflux". At 7 months, I found a much better ENT who diagnosed me and had me take 2 Nexiums together (80 mg) at her office. For the first time in 6 months, I stopped coughing in about 30 minutes. Just stopping the coughing was a major improvement, so I often say that my major leap was on the first day. Still, it took about 2-3 weaks for the runny nose and sinusitis-like condition to fully go away.
I was wondering if you cough at night? A lot of LPR patients feel best when lying down, treated or untreated.
I've personally tried Prilosec OTC and Protonix for short periods after starting the Nexium. Neither of those other drugs worked for me and I went back on the Nexium. I haven't been tempted to switch around at all in the last 2 years as it's hard to imagine feeling better than I do.
However, I do take an occasional Zegrid before bed when I have breakthrough reflux.
Give the Prevacid a chance - it might work. For some reason, most people here seem to be placed on Prevacid by their doctors first. It seems to be very very popular with the MDs.
However, if one PPI doesn't work for you, just move on to the next. Try each one if you have to at the double dosage level because PPIs are the best treatment out there for LPR. Lifestyle changes that I found important as well include not drinking soda, eating smaller meals, cutting out fried foods and fatty meats, and limiting chocolate. But I love food and eat everything at some point.
I hate to say this - but your job may be the cause of the problem - if you really have to talk 8 hours a day. Many singers get LPR - because they are overusing their vocal cords and larynx. You may be overusing your larynx in your job.