Thanks for the reply, but maybe I phrased it wrong. He is on many different kinds of drops, but nothing stops the mass forming in his eyes at night. I asked him if Patanol was one and he said yes. He also laughed and said thats like giving a guy who just had his arm blown off an advil (thats my brother). Anyway, his case is very severe, and from what I can tell from searching the internet, there may very well be nothing to do about it. I do appreciate the response and will keep checking back if someone has the magic answer. Thanks.