When I was using, I took 10/650's, and a lot of em. I was taking 24-26 per day of the 10/650 Lorcet. That's up to 260mg of opiates, and
16,900mg of acetaminophin, per day. And that was EVERY day. For 6 years.
I'm on suboxone right now, so hopefully that's all behind me. My pain mgmt. Dr had the foresight to have me take annual liver functionality tests. It's just a blood panel they run. My last one was approx. 8 months ago; the tests showed normal liver function. So I guess I'm just really blessed, so far. I don't know the long term effects (and I'm sure there are some), and I don't know how my liver is really doing. The tests I took were just a quick blood test. I'm sure there are more involved tests that can be done that will give you specific info on the state of your liver.
Looking back, I don't know how I'm alive, but I sure do thank God for it every day! Good luck to you.
-Kell