Gee every time I think that maybe I have another option, I hear bad reports and I get so very disgusted. Well, I have tried zetia for two days now, and I have to report that each time that I took it I developed terrible stomach pains and gas. This is very very very discouraging being that I went off the zocor and was hoping to replace it with this pill. I finally got up the courage to take it, and now I don't know what to do since I am sitting here with a bad stomachache. I don't know what I would rather have- leg pains from zocor, or a stomachache from zetia. What a choice?? The lopid also gave me stomach pains. I have IBS and I have to be so careful as to what I take internally. I did not try the niacin yet, but you said that you developed joint pains? I have never heard of this. NO one else on this board has reported this.