I think this happens to women. Prometrium [progesterone, I believe] has a negative effect on many women. Some women are ok with Prempro, it helps their sad feelings. Not so for me, I needed Prozac. What a difference! I am happier, and have my life back. This is very common; menopause exacerbates depression. I was crying and sad and anxious all the time. It hurt relationships, job, etc. Show your mom your message. I am 56 years young and tried various antidepressants. I was diagnosed by 2 psychs, and my family doctor. I assure you I am and was always sane and swift and I did not want to try Prozac because of the media stories. It takes a little time, and she may need a different med, but start low and gradually up the dose. The right med can change her life. My friend is 11 years on Prozac; she's slim, funny, and works as a legal assistant/paralegal which is not an easy job. Good luck to you and your mom.
Joy