What it sounds like it that you have some type of an allergic reaction to something. Since it is on your hands, the first question I have is do you wear artifical nails, (even if you have been wearing them for along time, and this has never happened before in the past)if so your nail tech has probably used something new on you, that she has never used before and if that is the case, you need to contact her and find out what(every product) that she used on you. It could be a number of things...if she has changed her glue, the primer, monomer, ETC.....but if you don't wear or have never worn artifical nails, Make a list of all the substances that have come in contact with your hands, other then what you normally have been using, maybe hand lotion, dish soap that you have changed. I am by no means a Dr. but it sounds like some type of dermatitis and you need to be seen by your DERMA DR. soon....you could try an over-the-counter hydrocortisone cream and see if that helps....but has soon as you can see your DERMA DR......hope this helps....