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Old 12-19-2012, 01:24 PM   #1
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Avolex for sinus infection

I was back at my ENT's office today and he decided to order another CT scan to see if anything has changed since my last one 1 year ago. That first scan, according to the radiologist, showed nothing out of the ordinary. This time, My ENT will look at.

In the meantime, he has prescribed me Avolex for 10 days. I had used Amox/Clav for 10 days a few weeks ago and it seemed that my facial and head pressure was somewhat diminishing, although far from gone. That was prescribed by my GP. I guess my ENT wanted to try something different and gave me an rx for Avolex. I decided to read up on it and what I came across was not good at all. I have a tendency towards anxiety, and it seems that the side effects of the drug can significantly exacerbate it. I had also read about irreparable damage to tendons. My question is if anyone on this board has used this drug and what your experience was with it? I'm especially afraid to use it, in addition to the above side effects, because an infection has yet to be confirmed by CT.

Thanks so much, in advance!

 
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Old 12-19-2012, 06:35 PM   #2
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Re: Avolex for sinus infection

I've taken it many times without any side effects. Avelox is generally very safe and the side effects you're reading about happen to a very small percentage of people (and are much less dangerous than repeated CT scans).

One other note you may want to consider - CT scans don't confirm the presence of an infection. They can confirm inflammation, a sinus blockage and a sinus that is filled with something other than air (which is what they're supposed to be filled with), but you really need a bacterial culture to confirm an infection.

 
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Old 12-19-2012, 07:02 PM   #3
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Re: Avolex for sinus infection

Whatever antibiotic you take, you have to take for a minimum of 21 days and 30 is better. A 10-day course won't help...it's like tamping down a fire that flares back up as soon as you walk away.

 
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Old 12-19-2012, 09:17 PM   #4
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Re: Avolex for sinus infection

@Cold247 - Avelox is Moxifloxincin. I've had three courses of it. I was unfortunately one of the unlucky few to have the side effects from it. Those included tingling/pins and needles in my hands, arms and feet (very uncomfortable), extreme anxiety (I managed to convince myself while I was on it that I had some sort of dreaded disease and my doctors werent telling me about it) and terrible chest pain. I was a rough few weeks while I was taking it but most side effects disappeared about a week after I finished each course. Except for the tingling in my hands and feet. I still get that on and off but it isnt nearly as intense as it was while I was on the meds.

I will at admit that while I was on the first course I felt better for a few weeks. So if my sinusitis wasnt chronic it would probably have worked. I only figured out on the third course that it was the the moxifloxicin causing the side affects as I was on other medication as well.

According to my ENT, moxifloxicin is one of the last antibiotics that people havent become resistant to and still works for sinusitis. But I won't take it again. For me so not worth the trouble.

But everybody is different. There is no guarantee that you will have such severe side effects on it. But if you do, call your doctor immediately.

Hope that helps

 
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Old 12-20-2012, 04:02 AM   #5
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Re: Avolex for sinus infection

I didn't know that you can't see infection on a CT scan. My ENT said that fungus has a certain pattern that shows on CT scans, and I guess I assumed the same for bacterial

I don't know why they keep giving me 10 and 14 day courses since, it seems that minimum three weeks is what it should be.

Last edited by Administrator; 01-13-2013 at 12:44 AM.

 
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Old 12-20-2012, 07:37 AM   #6
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Re: Avolex for sinus infection

@cold247 - My sinus issues have been managable for the past 4-5 weeks. As long as I use my neti pot once to twice daily it's bearable. I don't feel healthy or anything but the severe symptoms are gone. I still have pressure, breathing problems,headaches and a post nasal drip from time to time. But these symptoms are a picnic compared to what it was like before (inflamed, swollen throat, toothache, facial pain and swelling, red burning eyes. yellow mucus, cough, neck pain, dizziness, constant exhaustion etc in addition to the ones I still have). If I stop using the neti pot for even two days they all come back.

I'm having surgery in 5 weeks (counting the days), to straighten my septum, reduce/remove as large concha bullosa, scrape out infected tissue and remove nasal polyps. So hopefully that will do the trick, if not I'm at a loss because I have no idea what is causing my infection or whether it's fungal or bacterial. I suspect bacteria. But I guess they will be able to tell me after the surgery.

I was reading over your previous posts, you say that your CT scan came back normal a year ago? Does that mean no deviated septum, polyps, obstructions or anything like that? You and I have had very similar symptoms. Have you been exposed to mould at all? I have twice in the past 3 years and I've wondered if it was the cause of my infection?

I still think pollution and chemicals play a large part in sinusitis. Humanity is destroying the planet, maybe it's coming back to bite us through our sinuses.

Keep me updated if you find a cause and I will likewise

 
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Old 12-20-2012, 11:53 AM   #7
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Re: Avolex for sinus infection

Quote:
Originally Posted by Serenity0202 View Post
@cold247 - My sinus issues have been managable for the past 4-5 weeks. As long as I use my neti pot once to twice daily it's bearable. I don't feel healthy or anything but the severe symptoms are gone. I still have pressure, breathing problems,headaches and a post nasal drip from time to time. But these symptoms are a picnic compared to what it was like before (inflamed, swollen throat, toothache, facial pain and swelling, red burning eyes. yellow mucus, cough, neck pain, dizziness, constant exhaustion etc in addition to the ones I still have). If I stop using the neti pot for even two days they all come back.

I'm having surgery in 5 weeks (counting the days), to straighten my septum, reduce/remove as large concha bullosa, scrape out infected tissue and remove nasal polyps. So hopefully that will do the trick, if not I'm at a loss because I have no idea what is causing my infection or whether it's fungal or bacterial. I suspect bacteria. But I guess they will be able to tell me after the surgery.

I was reading over your previous posts, you say that your CT scan came back normal a year ago? Does that mean no deviated septum, polyps, obstructions or anything like that? You and I have had very similar symptoms. Have you been exposed to mould at all? I have twice in the past 3 years and I've wondered if it was the cause of my infection?

I still think pollution and chemicals play a large part in sinusitis. Humanity is destroying the planet, maybe it's coming back to bite us through our sinuses.

Keep me updated if you find a cause and I will likewise
My CT scan last year showed a mildly deviated septum and a small retention cyst but was otherwise "unremarkable". It was ordered by my GP and no one other than the radiologist actually looked at it. So who knows if I had an ENT at that time take a good look at it - they may have been able to pick up on something more subtle yet brewing. This time, my ENT will personally look at it. He did an endoscopic exam and he said that I have a very crooked septum. No polyps in my nasal passage. Problem is I have NEVER had sinus issues in the past. So unless a septum can worsen as one ages, I'm doubting that it's related to my present issues.

I was in Mexico about 6 weeks prior to my symptoms starting. Beautiful resort, but the rooms smelled badly of mildew. So I wondered if maybe exposure to more heavyduty quantities of mold might have triggered a reaction in me back then. I had read somewhere that sinus fungus is slower growing. My ENT said that fungus has a recognizable shape/pattern on a CT scan so we'll see what happens.

One of the other strange things for me is that I haven't had any nasal discharge whatsoever. Do you have discharge? Runny nose? I realize that one can have a sinus infection without these things but it just seems odd to me. Do you think the netipot alone is helping or have you been combining it with ABs? I have flushed the lights out of my nose with the neilmed bottle but it didn't help at all.

I also have an allergist appt scheduled for mid January to see if allergies are playing a role in all this. I most certainly will keep everyone updated on my progress and I look forward to hearing more about your journey!

 
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Old 12-20-2012, 11:18 PM   #8
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Re: Avolex for sinus infection

@Cold247

I understand how you are feeling... the constant pain and pressure, yet no obvious signs of infection (i.e. discharge) can really get you down.

I think that it is likely you have an infection that is locked in. I had constant headpain since June that was unresponsive to painkillers but no discharge at all. CT scan in August supposedly showed nothing other than deviated septum and concha bullosa. All through June & July I was flooding with saline and using psuedephedrine. The pain was getting worse so I started taking amitriptyline and sleeping tablets at night. Finally got a course of Amoxicillin (just 7-10 days I think) and another CT scan 2 weeks latter showed infection! That was 31st October.

After I started peroxide flushing about a month ago, the infection was "released" . The amount of dicoloured discharge got worse, but was at least started to come out! It was like a dam had been opened! I was on Doxycycline 10 days , Keflex 7 days, Discharge still really bad so on Clarythromycin 7 days, and infection started to ease up, but not gone completely as still had discharge when I flushed. Now been on Augmentin for nearly 2 weeks....a total of 5 antibiotics, and I still think it is lingering in the depths of my head! Last doctor I saw agreed that Antibiotics need to be taken longer than one week! Quote "Just because one clinical study shows that most people respond in 4-5 days doesn't mean that everyone will!"

Also, I'm not sure if a netti pot actually reaches deep sinuses...does it not just flush out the nasal areas?

I flood my sinus for up to 10 minutes, front and back by laying on bed with head hanging over edge...but don't know whether this gets the fluid further into the ethmoid & sphenoid sinus or not.

@gcsjr I'm confused as you say a CT scan doesn't show up infections. I was under the impression that a CT scan was the best way of diagnosing infection, and three different doctors I have seen in last 4 weeks have said that my CT scan (from 31st October) shows infection in ephmoid/sphenoid sinus.

Of course they are could just be assuming that the liquid gunk built up inside my sinus are infected due to the colour of discharge. And the fact that I have no energy and get out of breath quickly etc.

 
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Old 12-21-2012, 06:18 AM   #9
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Re: Avolex for sinus infection

I think you're spot on right about what the neilmed bottles are effective at doing - which is clearing nasal passages. I don't think they're powerful enough, in terms of force, to get into hard-to-reach sinus cavities. So where are you at now, Nightwarrior? Are you feeling better enough to continue what you're already doing or is there talk of surgery?

Last edited by Administrator; 01-13-2013 at 12:46 AM.

 
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Old 12-21-2012, 06:51 AM   #10
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Re: Avolex for sinus infection

@cold247 I am feeling significantly better than I did 4 weeks ago...I'm kinda getting used to this sort of "normality"! I was told by GP receptionist to phone Christmas eve if nothing has changed over weekend. Although my congestion has gone down a lot and the pain has significantly decreased, I am still concerned that I still have disgusting coloured mucus, normally an hour or two after waking, and again early afternoon, and a bit of mild cheek pain ( as opposed to right between the eyes).

Sinus flooding with saline seems to help flush out some of it, but every day there is more! So I worry that if i stop the antibiotics, it may get worse over the holiday when the GP is closed.

I'm not sure I want surgery, but may agree to a bit of endoscopic vacuum cleaning, if they can do that! I'm due to see ENT specialist New Years Eve...and last time I saw him, he did say he could correct deviated septem and open up concha bullosa to improve drainage. But I'm not really sure that's the solution, and I'm also concerned that many people seem to get post op infections and back to square one again!

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Old 12-22-2012, 10:59 PM   #11
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Re: Avolex for sinus infection

First of all, I dont think a radiologist is qualified to read a sinus CT scan. It's a good thing that you went for another one. You asked about nasal discharge. I do get nasal disharge from allergies but not from my sinus infection. So personally I dont think it's too strange not to have a sunny nose with a sinus infection. I havent had one. Just a bad PND.

In fact when my sinus infection started in march my sinus symptoms were so sublte that I was only diagnosed with a sinus infection in august. It probably had a lot to do with my first GP, he didnt examine me to thoroughly and just kept plying me with antibitotics. My main symptom was a swollen and inflamed throat so he kept diagnosing a throat infection. It never occured to him that it was being caused my PND. I had sinus pressure and low grade headaches but he paid no attention to them and just treated my throat. It was only when I got sinual bronchitis in August, passed out in a shopping centre because I couldnt breath and landed up in the emergency room that the ER doctor diagnosed a severe sinus infection and referred me to an ENT. So yeah, to cut a long story short, not having a runny nose doesnt mean anything. The mucus could just be going the other way, down the back of your throat and that brings me back to the deviated septum interferring with mucus drainage. But again, this is just my opinion based on my research.

As for the neti pot, I am using the neti pot alone without antibiotics. I'm taking Allergex for allergies and using steam with inhalant oil for congestion but no other medication and I do feel better. I finished my last antibiotic during the third week of November. It was 400 mg Moxifloxicin (Avelox) and on the second last day of it I still wasnt feeling better (and I was experiencing all the awful side effects that I mentioned in my first post) so I went out and bought a neti pot. I didnt notice a difference straight away but persisted with it, using it every morining. I boil the water to sterilise it and use 1/4 tsp sea salt and 1/4 baking soda to 250 ml luke warm boiled water. After about two weeks I woke up one morning and realised that my throat wasnt sore anymore (first time in 8 months!), then the severe facial pain went, then the severe sinus headaches, upper tooth & jaw pain, fatigue, blurry vision, yellow mucus all went. So I've just kept using it and now I can function again.

So that's my whole story...I am a huge fan of natural remedies now. I'm taking homeopathic supplements and vitamins as well. I believe that garlic and grapefruit seed extract cure sinus infections too as well as drinking water with apple cider vinegar. And I eat a lot of wasabi because it has antimicrobial (antibacterial) and anti-inflammatory effects.

I was reading up on ways to indentify sinus infection causes and I came across this procedure call a sinus puncture For this test, the sinus cavity is punctured with a needle, and a sample of the sinus contents is obtained. A culture and sensitivity test is often done on the sample to identify the bacteria, virus, or fungus causing the infection and to determine which medicine will be most effective in treating it. Cells taken from the sample may be studied under a microscope. The sinus cavity is then usually flushed with saline solution.

Worth a shot I think. I'm going to look into it in January.

Last edited by Administrator; 01-13-2013 at 12:51 AM.

 
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Old 12-24-2012, 07:30 AM   #12
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Re: Avolex for sinus infection

Maybe I didn't give the neilmed bottle a long enough run. I also tried to drink organic ACV but, again, maybe didn't do it long enough.

Have you looked into LPR (silent reflux) by any chance. Since you mentioned PND and sore throat I thought I'd throw that out there. Apparently the acid can inflame your sinuses and doesn't neccessarily cause traditional GERD symptoms.

I've taken two doses of Avelox and so far no side effects at all. Not doing much to make me feel better as yet but I know it's still early. I have another CT scan next Friday. Wishing you well over the holidays!

 
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Old 12-24-2012, 08:43 AM   #13
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Re: Avolex for sinus infection

@cold247 - I'm a big believer in sinus irrigation but you need to persist with it to see results so maybe give it another shot. It can't hurt.

Actually LPR was the first thing my ENT treated me for before the CT scan. I was on Nexium 40 for a month and it didnt make any difference. I truly believe the surgery is my last option. I've literally tried everything else. The sinus irrigation helps but hasnt completely irradicated my symptoms, I still have to take a lot of painkillers and I can't carry on doing that forever. Not if I want to keep my kidneys and liver.

Glad to hear you're not having any nasty side-effects on the Avelox. Best of luck with it and hopefully it cures your infection before you have do to anything drastic like surgery!

Wishing you and your family a very Merry Chirstmas and luck with your CT scan. Hope you finally get an answer

Last edited by Serenity0202; 12-24-2012 at 10:23 AM. Reason: spelling mistake

 
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