It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....

Sjögren's Syndrome Message Board
Post New Thread   Closed Thread
LinkBack Thread Tools Search this Thread
Old 01-20-2011, 01:31 PM   #1
syrob's Avatar
Join Date: Jan 2011
Location: Sacramento, CA
Posts: 6
syrob HB User
Question Anyone else had GI upset with NSAIDs but, has been able to tolerate Plaquenil?

Hi everyone,
I have often visited this message board to read the posts but I had never registered, until today. The posts I have read have helped me to know what others with the same condition were going through. I appreciate everyone sharing their stories. I have been diagnosed with Primary Sjogren’s Syndrome, after ruling out Lupus. I have joint pain, fatigue, and the typical dryness; along with many other symptoms. I was also diagnosed with Fibromyalgia. I recently changed Rheumatologist after many years with a Rheumy whom I just loved but who was not covered by my insurance I finally got a Kaiser Rheumy, he came highly recommended. He would like me to try Plaquenil, which is what brought me back to this message board. As usual I have found some who have had success and some with not such good results. I have decided to give it a shot, I have once again had GI upset with the latest NSAID, I have run out of options and Plaquenil seems like the lesser of two evils. His other suggestion was Methotrexate, I’m not ready to go there. My biggest worry is that all the common side effects are what I usually have trouble with on NSAIDs. Anyone else had GI upset with NSAIDs but, has been able to tolerate Plaquenil?

Sponsors Lightbulb
Old 01-20-2011, 03:54 PM   #2
Senior Member
Angie10's Avatar
Join Date: Apr 2007
Location: MA, USA
Posts: 216
Angie10 HB User
Re: Anyone else had GI upset with NSAIDs but, has been able to tolerate Plaquenil?

Hi Robin,

The first medication I tried was plaquenil in the generic form and had to switch to the name-brand due to intense itching and rashes. Eventually, I had the same reaction with the name-brand. It also was not working anymore because the flares and pain had become so great. I had to add prednisone to get through the winter. However, so many people tolerate the plaquenil with little or no side effects.

I have been on injectable methotrexate for over a year now and have noticed a tremendous improvement. My flares have been reduced dramatically and the only real side effect is fatigue (which I already had) and some nausea on the day of the injection.

I also have Fibromyalgia and take Celexa and Neurontin to aid with those pain symptoms. I use Restasis for my dry eyes and sleep with a humidifier at night to help with dry mouth and nasal passages.

Please bear in mind that it takes around 4 months to see the positive effects of the plaquenil, but once it kicks in you feel so much better. Best of luck to you and hope you feel better soon.



Old 01-21-2011, 06:26 PM   #3
syrob's Avatar
Join Date: Jan 2011
Location: Sacramento, CA
Posts: 6
syrob HB User
Re: Anyone else had GI upset with NSAIDs but, has been able to tolerate Plaquenil?

Hi Angie,

Thanks for the advice.

I also have fibro; I had a lot of anger issues on any of the anti-depressants I took. My doc at the time said I probably should not try any of the others. Also, I have tried Lyrica, without success.

Have you heard of taking Folic Acid for the nausea associated with methotrexate? I wonder if Folic Acid works to combat nausea with other meds.

I took my first 200 mg of the generic plaquenil this morning and no nausea. I always have itchy skin, so I hope I won’t have to deal with that side effect. Although I have heard that an antihistamine can calm the itch.

I found a wonderful natural substance that has helped with my fatigue: D-ribose. It is not a miracle but I now can stay awake after dinner till about 10pm. I used to get home from work at 5:30 fix dinner and go to bed. Now I feel I don’t need 10-11 hours sleep, a solid 8 does the job. I take 1 scoop (5 grams) in the morning in my coffee and then another scoop at lunch in my juice. If I take it late afternoon I have trouble falling to sleep. But 3 scoops a day are recommended. I first bought the Corvalen brand which is the one that was recommended to me but have since purchased a generic which seems as good, and much cheaper.

I can’t wait to feel better. It’s been far too long since I felt good. Thanks again.


Closed Thread

Similar Threads
Thread Thread Starter Board Replies Last Post
question on Plaquenil eglingirl Sjögren's Syndrome 3 11-16-2010 12:58 AM
Anyone using a stronger DMARD than Plaquenil? Angie10 Sjögren's Syndrome 0 10-08-2010 08:44 AM
Anyone on methotrexate? Angie10 Sjögren's Syndrome 2 06-07-2010 07:14 PM
Is anyone else able to work full time? megand bjsmom Sjögren's Syndrome 5 08-05-2008 01:00 AM
Plaquenil laelizalde Sjögren's Syndrome 1 04-06-2008 01:32 PM
what side effects can be caused when taking both prednisolone and plaquenil agraham Sjögren's Syndrome 0 03-03-2008 08:50 PM
Does anyone have "spells" ? october885 Sjögren's Syndrome 6 09-30-2007 09:10 PM
Feeling awful - can anyone relate? kelltic Sjögren's Syndrome 15 02-08-2007 06:58 PM
Sjögren's syndrome - Anyone here with this? MilkNWheat Sjögren's Syndrome 45 05-25-2005 11:06 AM

Thread Tools Search this Thread
Search this Thread:

Advanced Search

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is Off
HTML code is Off
Trackbacks are Off
Pingbacks are Off
Refbacks are Off

Sign Up Today!

Ask our community of thousands of members your health questions, and learn from others experiences. Join the conversation!

I want my free account

All times are GMT -7. The time now is 09:15 PM.

Site owned and operated by™
Terms of Use © 1998-2015™ All rights reserved.
Do not copy or redistribute in any form!