I have episodes of itching, all over. I use Eucerin Cream, which 2 dermatologists recommended and I still itch so I am convinced it's systemic and nothing topical will help. It's torture, I know...I scratch and can't stop, from head to toe, I even sit here with a backscratcher. Then I'll go months with nothing. When it gets too much to bear, I take a Benadryl, which helps. I don't think I will ever find the cause, sometimes I get little pinpoint sized bumps in the inside of my arm, and this is when the itching acts up. I have been tested for allergies, all negative. It's a mystery...see a dermatologist if you can.