If it is the palms of your hands, you can file the rough, dead skin smooth with an 80 grit fingernail file. You can find the large ones at a Sally Beauty Supply. Simply file the skin where the callous has formed, or where the dead, rough skin is, but do not attempt to get rid of all of it at once -- You will just end up making your skin sore.
You can purchase Jojoba Oil at your local Health Food Store, and mix it with Sweet Almond Oil, Rice Bran Oil and Vitamin E Oil. This combination of essential oils will help to heal your hands, making your hands/skin soft and conditioned.
Mix 4oz Jojoba Oil with 1oz of Rice Bran and Sweet Almond OIl and 1/2 oz. Vitamin E oil. this will give you enough oil to last at least 6 months if not longer. You can use this oil on your hands, feet or your entire body. Apply to hands/feet at least twice daily and you should see dramatic results in about 2 weeks. YES, we DO care if your hands and feet are rough!