Re: If Lunesta Works For You, How Long Before Bed Should You Take It?
In healthy normal subjects ( I am assuming this is you all), the pharmacokinetic profile after once-daily administration of 1, 3, and 6 mg for 7 days shows eszopiclone(Lunesta) is rapidly absorbed. The time to peak concentration is approximately 1 hour. With a terminal-phase elimination half-life (t1/2) of approximately 6 hours (so once at max it should hold you in the sleep state for six hours.). In healthy adults (you all I hope), Lunesta does not accumulate with once-daily administration, and its exposure is dose-proportional over the range of 1 to 6 mg. (This means it will not buold to toxic levels in your system and the dose that works for you between 1-6 mg should stay that way.)
Absorption And Distribution
Eszopiclone is rapidly absorbed following oral administration and thus you need only take it within the hour of your desired bed time. Peak plasma concentrations are achieved within approximately 1 hour after oral administration.
This is the laymans interpreted pharmacological data for you.
If we learn by our mistakes, I am working on one hell of an education.