The adrenals work together with the thyroid (in terms of absorbing the thyroid hormone) and that's part of my problem too for certain (I have the symptoms), but the doctors won't believe that one for a second. Like I say, it says to check and correct adrenals first in the prescribing info for the thyroid supplements.
But with the way supplements work, you take them, they get into your system as FREE hormones, and then your body uses them. If your reserves are low enough (and they will be if you don't take enough), you will have a spike and then a run-out as the day progresses and before you can take the next dose.
The thyroid gland itself works much differently than the supplements do. The thyroid puts out this protein-complex which contains many T4s, T3s, etc...this is the "time-release" storage aspect. These proteins are stable and will float around in your blood as long as possible. When your thyroid is signaled that the free hormones are needed, the protein structures are taken in and broken apart.
Of course, the hormones themselves have different functions. T3 is really unstable, with an 8 hour half-life, so it has to be "protected", so the T4 acts as the storage end of it, and works better that way (6 weeks). T3 is used in part to create the chemical energy the cells need.
The catch here is that if you look at the conversion from T4 to T3 chemically it's going from a stable to unstable state. In chemistry the general rule is that if you go to a unstable state from a stable one it takes energy to go INTO THE PROCESS
to do so. So we can actually have enough T4 in our systems, but not the ability or the energy to use it. This is where the T3 supplementation becomes handy, and the reason why the thyroid secretes T3 along with T4, and not just T4, and where the stupid doctors go wrong in giving only LT4. It's not that the body's cells are able to convert the T4 readily, the question is whether it is able.
The T3 is a limiting factor here, but so is the amount of T4. Since the majority of what the thyroid does produce is T4, if the ability to produce T4 is down, then it must be supplemented. And if the supplements are not providing enough, you'll get the "boost" from the time you take it until it draws down in the day to be "not enough".
I noticed this (and still do now) myself especially when I was on an insufficient amount of LT4 only. I'd feel relatively OK when the supplement would get into my system, but when 7pm or so would roll around, I'd get really sensitive to cold, my joints would start aching profusely, and I'd start to ease into an unexplainable depression. I don't notice this stark difference so much anymore, but I still notice it.
Hope this helps explain what I was getting at...what amazes me is how easy I've been able to research and find all this out and be able to understand it, yet the doctors who go to medical school for years and are PAID
to understand this can't seem to.
I'm thinking of writing up a description of the progression of hypothyroidism and the different supplements' effects on you. It might be very interesting, and very enlightening to everyone except the medical people. If I do it might be very interesting to get some feedback from people to see if they observe things the way I think things happen.
Originally posted by Iwannalife: |
Sky, The sinking toward evening could have to do with adrenals too? I thought with T4 drugs your liver just converted as needed after it builds up in your system? When your thyroid(if it's healthy) puts out the hormones, some is for use immediately and some (T4) is kind of like time release. Why did scientists get the idea they could skip a step, especially on people who take these meds for a lifetime. Arrogance/$$$? IWL