Does anyone out there have any information or suggestions as to resources where I can learn about antibodies? My daughter has very, very high antibodies and has been diagnosed with Hashimoto's. I'm wondering if the level of antibodies ever decreases, and if so, how that has been done. If she had one number on a blood test, and then a lower number on a subsequent blood test, does that mean the antibodies are actually decreasing? Or since the level is still WAY above the "normal" range, does it simply mean that she has an autoimmune situation? Thanks for any help!
You've asked a good question, but it seems none of us has a good answer.
What I do know for fact about TPO ABs isn't much, but here goes ~
They have been associated with increased risk of infertility and miscarriage. Your daughter should seek the advice of an OB skilled in treating thyroid disease should she want to attempt pregnancy.
Supplemental selenium in the amount of 100-200/mcgs per day has been shown to reduce TPO AB numbers in some cases. Your daughter should try that to see if it will make a difference.
Once the thyroid has been destroyed by the ABs, they should clear the body and exist no more.
I thought at one time I read that treating with thyroid hormone therapy would in some cases reduce ABs... But I no longer remember the source, if in fact I did read it.
Otherwise, I suppose if there were a surefire way to eliminate them, there would be no more Hashimoto's in the world. If only...!
That wasn't much help... but I can't find much about reducing TPO antibodies on the Net.
Thanks for the quick reply, Midwest1. I appreciate it! I'll keep searching and let folks know if I find anything more. I too haven't had much luck finding anything definitive about high levels of antibodies.
I think the antibodies fluctuate over time, up and down. The antibodies "flare" which cause hyperT symptoms. The flare causes another decrease in thyroid function which causes hypoT symptoms. I've read that high titers of thyroglobulin antibody are common in Hashi's.
Since we're discussing antibodies here, I have a question - how high is high? My thyroglobulin AB was 6.7 with a range of 0-2. I know it's out of range and I've been diagnosed and am being treated, but would that be considered high or just mildly elevated?
I also have Hashimoto's. Research is pretty slim on this and you have to do a lot of digging. I found pretty much everything under Auto Immune Diseases. T-Cells fluctuate. They can read normal at some times and others are high. The Thyroid itself could be normal. My disease is attacking my body. Muscles, joints and brain. About all that can be done is wait for the Thyroid to be destroyed or removal of the Thyroid, and they don't like doing that. But you do have what is called "Remission" stages. You could be fine 1 week and the next down. It's an auto immune disease and will always be there. Good luck to you and your daughter and stay on top of this. Watch for fatigue and muscle weakness, even hair loss. The hair will come back though.
Thanks to everyone for their ideas and sharing of personal situations. Fortunately I like doing research, but I have to admit that this topic isn't very easy to uncover! My daughter's endo is setting up an appointment with a thyroid specialist so if I learn anything more I'll be sure to share it.
One more thing I forgot....
The book Living Well With Autoimmune Disease discusses antibodies' role in AI in great detail. Some of the information is only speculative, because there is still a lot to learn about what goes wrong to cause these diseases, but it's worth trying. There are suggestions for some things you can do that might help control the numbers of antibodies.