I had my thyroid removed in June this year. I wasn't in any pain in the 2 days that followed, but then some discomfort set in and it felt like a sore throat and muscle pain in my neck. It only lasted a few days. I didn't even need the pain killers that were prescribed for me. The cancer was so small, and in the right lobe only (which had actually been removed 2 years ago.) so I didn't need radiation or chemo of any kind. I was put on 100 mcg of Levoxyl.But in the 2 weeks that followed I gained 6 pounds. I got the med upped to 125 mcg, but in the following 2 weeks I gained another 5 pounds for a total of 11 pounds. My blood work showed that I was on the high end of "normal." So I asked to switch to Armour Thyroid. I switched about 2 weeks ago, (to 75 mg) and haven't gained any weight. I am trying to lose the weight now. I haven't had any depression or any other symptoms, except I am tired all the time and hot(?) I also went through a trying time since my Mom just passed away, which many of you know out there. So,. I am depressed and feeling blah, but I think that has more to do with my life than my meds. I am waiting another 2 weeks or so to get my blood checked, and hopefully I can get it all straightened out. From what I know, it takes a good 4-6 weeks to get stabilized, but I think you can talk to your doctor and let him/her know what you are feeling, so that adjustments could be made without waiting. Every doctor is different. I am lucky, my doctor listenened more to me than to the bloodtests. Good luck to your Mom.