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Old 09-11-2004, 01:34 AM   #1
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Felix73 HB User
Afternoon slumps

Hi there,

I've been on thyroxine for hypo for just over a month now and am starting to see some benefits. I've upped my dose to 87.5 mcg which I am splitting between first thing in the morning (75mcg) and mid-afternoon (12.5 mcg), but I am still getting bad energy slumps by 2pm and needing those naps.

I can't take the meds too near bed time as they keep me awake.

Can anyone advise me on why this is still happening please? Is my dose still too low?

Thanks in advance,

Felix x

 
Old 09-11-2004, 12:01 PM   #2
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Re: Afternoon slumps

I might be totally wrong about this, but I am not aware that splitting a T4-only dose will accomplish the p.m. boost that you're seeking. If anyone else does this, please chime in here and let us know if it works and how well it does.

The reason splitting a T4/T3 natural med or synthetic Cytomel works is because T3 is short-acting... the half-life is only about 6 hours. So taking two doses of T3 gets you through the day with a continuous supply. The half-life of T4 is much, much longer... although I can't remember right now just how long.
Without any T3, there's no point in splitting.

 
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Old 09-11-2004, 12:23 PM   #3
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Re: Afternoon slumps

The half life of T4 is about one week, whereas the half life of T3 is about one day. The best way I've heard it described is that T4 is like the food in your fridge and T3 is like the food on your plate

Felix, it can take 6 weeks until you 'see' the difference in a dose change with T4, so things might improve yet.

Nat
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Old 09-11-2004, 01:00 PM   #4
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Re: Afternoon slumps

Thanks Midwest and Gopherhead,

I guess I will just have to persevere with it until things settle down. It's just wierd how, about 2 hours after taking the thyroxine, you feel good and then it just seems to wear off.

Worth a try but I'll stop splitting it if it doesn't work.

Thank again,

Felix x

 
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