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Old 02-15-2005, 09:10 AM   #1
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TSI Antibodies - Calling all Graves' Experts please!

So for the first time in my life I finally got a TSI test. I've been diagnosed with Hashi's for a while now. My labs usually fluctuate wildly, but I've never had a hyper lab result out of like 60 sets of labs. I do get hyper symptoms from time to time though.

Can any of you experts tell me if you ever had a TSI test done and if so, what were your numbers like?

Also, do the lab results below actually confirm Graves' Disease AND Hashi's at the same time? I am still not on any meds cause my Free's have always remained perfect even though my TSH is all over the place.

Thyroid Stimulating Immunoglobulin

TSI Quantity 1.6 High Index Reference Range <1.3

Reference Range for TSI:

Less than 1.3.........not detected
1.3 - 1.5...............Indeterminate
Greater than 1.5 ....Detected

TSH 14.8 HIGH
T3 Total Middle range Normal
T3 Free Low Normal
T4 Total Very Low Normal
T4 Free Middle Range Normal

Thy. Glob AB and TPO AB very high for both

 
Old 02-15-2005, 12:26 PM   #2
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Re: TSI Antibodies - Calling all Graves' Experts please!

Nasty, I'm no expert but I did find a few articles on pubmed which confirmed that TSI antibodies are often found in Hashi's patients, even in those who've not been treated. This is an excerpt from the Journal of Clinical Endocrinology & Metabolism, Vol 48, 572-576:

Thyroid-stimulating immunoglobulin (TSI) activity was measured by radioreceptor assay in sera from patients with Graves' disease, Hashimoto's thyroiditis, and thyroid cancer. In untreated Graves' disease (47 cases), TSI index was significantly lower [76.7 +/- 1.4 (SE)] than the average of a normal control group (30 cases; 94.4 +/- 1.9). In untreated Hashimoto's thyroiditis (25 cases), it was also significantly lower (83.0 +/- 2.4). In patients with thyroid cancer (19 cases), there was no significant difference from normal controls. After 131I treatment, the TSI index in Graves' disease decreased during 2--4 months, then increased and reached normal levels in 1 yr. During propylthiouracil treatment, the TSI index increased and reached a normal level in 5--6 months without the decreasing phase seen after 131I treatment. Free T4 index values were gradually decreased by both treatments. There was no significant relationship between TSI index and thyroid antibodies (microsomal antibodies and thyroglobulin antibodies) in untreated Graves' disease or Hashimoto's thyroiditis. It is concluded that 1) in the sera of patients with Graves' disease and Hashimoto's thyroiditis, there are immunoglobulin Gs that can displace TSH binding to thyroid membranes; 2) these immunoglobulins Gs are different from the classic antithyroid antibodies; and 3) 131T treatment of Graves' disease may enhance TSI production during the first 1--2 months after therapy.
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Last edited by Gopherhead; 02-15-2005 at 12:27 PM. Reason: speeling ;)

 
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Old 02-15-2005, 03:15 PM   #3
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Re: TSI Antibodies - Calling all Graves' Experts please!

I believe that the abstract is referring to the "TSI Index" which does not measure directly TSI antibodies. (I found it confusing)

TSI antibodies are directly responsible for Graves disease. See: [url]http://health.discovery.com/encyclopedias/1516.html[/url]

What I would guess is happening with you is that if your TPO antibodies (Hashi's) are much greater than your TSI antibodies (Graves), then TPO abs are driving the car, so to speak.

Some researchers believe that Hashi's and Graves are the same disease, just different ends of the spectrum.

An overwhelming majority of patients with Graves also test positive for TPO but we have TPO in much lower numbers (titres) than is seen with Hashi's patients.

Clear as mud now, right?
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Old 02-15-2005, 03:41 PM   #4
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Re: TSI Antibodies - Calling all Graves' Experts please!

Quote:
Originally Posted by K9Mom
I believe that the abstract is referring to the "TSI Index" which does not measure directly TSI antibodies. (I found it confusing)
It was confusing, K9Mom, but it was referring to antibodies as well, the first line was "Thyroid-stimulating immunoglobulin (TSI) activity was measured by radioreceptor assay in sera from patients with Graves' disease, Hashimoto's thyroiditis, and thyroid cancer. "

Quote:
Clear as mud now, right?
Your explantion was pretty clear, actually.
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Last edited by Gopherhead; 02-15-2005 at 03:42 PM.

 
Old 02-15-2005, 04:12 PM   #5
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Re: TSI Antibodies - Calling all Graves' Experts please!

The big question is what do I do? Im not messed up enough to take meds cause my Free's always seem perfect but have the ups and downs of symptoms associated with Hashis. From time to time I also experience tremor and hyper, symptoms typically associated with Graves.

Do I just nuke this thing already or leave it alone until the next time I feel crappy? I'm on a pretty good stretch right now....almost 20 days of somewhat normalness....its a 2 year record for me. I'm kinda waiting for the bottom to fall out from under me at any time now.

 
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