Re: TPO Question
TPO antibodies are the most common cause of hypothyroidism. After that, they really aren't as important as you'd think. Certainly the number isn't important. The lab that ran my test only counts to 70, then stops... because 70 is enough to confirm that the antibody level is sufficient to be causing Hashi's.
For people whose labs count each and every antibody, higher numbers don't mean those people are sicker than people with lower numbers, because symptoms don't correlate directly with antibody counts. I suppose, but don't know for sure, that higher numbers might destroy the thyroid gland faster than lower numbers. That's just conjecture on my part.
The only time TPO antibodies are of extreme importance is during pregnancy. High numbers are known to cause miscarriage, stillbirth, and pre-term labor.
Taking selenium in foods or supplement form has been proven to sometimes reduce the number of TPO ABs. It can't hurt, unless you take too much. Don't exceed 100-200 mcgs per day and you'll be alright.
Your dose is a starter dose for most people. It isn't surprising you've seen little improvement in two weeks. The full effect of a dose of T4 med isn't completely felt until 6 weeks after it's started. If you need a higher dose then, you'll need another 6 weeks to see what it will do for you. It typically takes a matter of months... not days or weeks.... to find the right dose that will eliminate all symptoms and stabilize hormone levels.
Hope that answered some of your concerns.