Hi Lady! I'm new to all this, since January, have hypo/hashi's. I was on generic the 1st couple months, got a new endo and he switched me to Synthroid. From what I've read you should stay with the same brand, and even with one brand pharmacies may substitute manufacturers, so that is not good. Some people do fine with generics, but I feel better with a brand name. You need to check your label each time and make sure its the same manufacturer, if not take it back. I think as far as "effectiveness" its really about keeping the same drug in your system, the problem comes when you get a variety of suppliers in the mix.
How long have you been on meds? It sounds like you have a lot going on with other issues? Diabetes is a top symptom/outcome from thryoidism. That part may get more normal over time. My dad is diabetic and just started Synthroid, 84! ( I had him ckd!
) His suger is getting more stable now! it was all over the place. Depression, blood pressure etc are all related sometimes. You may not need all those other meds, if your thyroid was to blame all the time!!!??? They in themselves have horrid side effects. Are you seeing a good endo? what are your recent levels, tsh t3'4's have they done anitbody testing???? Get your labs and lets all take a look?
Oh, insomnia!? I had horrid insomnia for about 20yrs!, I'm almost 52, and this is the first time I've not needed a drug to sleep since I got on thyroid meds!!!