Originally Posted by MAD MAZ
Hi ookissak I have had a Autoimmune Antibodies test still waiting for the results, MG is this the test that will tell us our thyroid level??
I thought it was one that tell us alot of different antibodies, like Ro antibody
La antibody, Sm antibody, Scl 70 antibody, Jo-1 antibody levels...Anti smooth muscle and a few more..
kassikoo I hope you start to feel better with your pains ...Mad Maz x
Here I go, MG's take and definition of your list:
General autoimmune antibodies are ANA - anti-smooth muscle antibody
Standard thyroid antibodies are...
TPOAb - 85 - 90% identifier for Hashimoto's thyroiditis 12.6 % of the population tested in over 20,000 patients have positive antibodies present. This could be an explaination of fibromyalgia.
TGAb - 60 % identifier for Hashimoto's thyroiditis
TSI - 75% identifier for Graves Disease
TRAb - 55 - 60 % identifier for Graves Disease
These are EXTRACTABLE NUCLEAR ANTIGENS are (SSA,SSB, RNP, Sm, Scl 70, Jo1) Screens for some of the specific antibodies you mentioned: Ro, La, RNP, Sm, Scl 70, Jo 1 are used in the following manner.
The main use for the tests you listed are is determining the presence of extractable nuclear antigen antibodies. These antibodies are a group directed at nuclear, and in the case of Jo1, cytoplasmic antigens, which have particular associations with various connective tissue disorders. And if you test positive for ENA antibodies you most likely will be positive for ANA antibodies as well.
Antibodies to Sm are found in a small percentage of patients with SLE(Systemic Lupus Erythematosus), but not all. These antibodies are highly specific for this disease.
Antibodies to SSA (Ro) and SSB (La) are the main identifiers and found in cases of Sjogren's syndrome, SLE, and congenital heart block. Note since there are three targeted conditions.. being positive in them with out being positive in others just indicates you may have one of these conditions.
Antibodies to RNP are seen in cases of mixed connective tissue disease (overlapping features of SLE, systemic sclerosis; and polymyositis) but may be associated with other connective tissue diseases such as SLE. They are using such a test and a few of the others to prove Lupus. It is part of a thorough fishing expedition to lump you as Lupi.
Okay.. two more. Antibodies to Scl-70 are found in 20 - 40% of patients with diffuse scleroderma and up to 20% of patients with limited scleroderma. These antibodies may be associated with a more severe disease course. Scleroderma aka systemic sclerosis is defined as a chronic connective tissue disease. It is also generally classified as one of the autoimmune rheumatic diseases. Once again they are fishing. Aren't you glad they are?
Last one, whew! Antibodies to Jo-1 are present in 25% of patients with myositis. This group tends to have associated interstitial lung disease. These antibodies are rarely seen in other autoimmune conditions. SO if you have this they will be able to classify you with mypsitis.
Is that what you wanted to know?