I was on Paxil many yrs ago. The first 3 yrs on it I was fine, no weight gain. But, the next 2yrs, I gained 30 lbs! I look back at those pictures and don't even recognize myself!!! This past October I was on a low dose of Remeron, for insomnia. Within about 2 wks the lbs were piling on!! I'm off it now, but the 10lbs I gained are still sitting there. My sister in law is on Paxil and she was fine for a few yrs, now she is HUGE! I've been hypo/ hashi's for most of my life and never had a weight problem, only with drugs! ( neurontin was another one they tried me on, I have spinal issues, I quickly gained weight with that too!) so for me, no more meds! only thyroid pill now can't get rid of that little guy. So in alot of cases meds could be the culprit??? There not easy to wean off, takes awhile, little cuts every other week. Wouldn't hurt to get labs done though!!