Hi Carol, Midwest is so right, it takes time with adjustments on meds. My new endo increased my Synthroid back to 75mcg and dropped t3--I'm back to horrid fatigue in the am. When I first started meds in January, I too, got worse! our bodies have been so depleted of hormones for so long it will take time to adjust. Most people on these boards are new to thyroid issues and seem to suffer so many symptoms, the long timers must be ok? Not sure what your situation is with female stuff, but I'm past menopause having had a hysterectomy yrs ago. My estrogen is high, they don't seem concerned. So I've added pro-gestrone cream to help balance out. Your depression is likely related to all this hormone stuff. Also other meds can cause a host of weird symptoms. Your thyroid is hypo, and your on the right track to healing now!!! See what you can do to rid any other meds and eat well, exercise, good nutrients/vit. and in time you will feel great!!! I truly believe having had a hysterectomy in my mid 20's and no hrt support put my body into a whirlwind of problems! so little by little adding back what they took out!!