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Old 08-21-2008, 07:44 AM   #1
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Question Antibodies - Tg and Tpo in Layman's Terms Please

I need a refresher, please. What do these antibodies signify? Is Tpo the anti-thyroid antibody?

Thanks!

 
Old 08-21-2008, 07:55 AM   #2
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Re: Antibodies - Tg and Tpo in Layman's Terms Please

I don't think I'm really all that qualified to answer, but because of my previous post and the test result being for antibodies, I googled my test, "TPOAb", and from what I read, TPO is thyroid peroxidase. That still doesn't help ME out though! I don't know what that means either!! hehe

 
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Old 08-21-2008, 08:50 AM   #3
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Re: Antibodies - Tg and Tpo in Layman's Terms Please

TPO (thyroperoxidase) is an enzyme in the thyroid gland that is important to the production of thyroid hormones. TPO antibodies attack the process that creates the enzyme.

Tg (thyroglobulin) is a protein which carries T4/T3 in storage through the bloodstream until it's needed. Tg antibodies attack that protein.

 
Old 08-21-2008, 10:36 AM   #4
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Re: Antibodies - Tg and Tpo in Layman's Terms Please

Quote:
Originally Posted by midwest1 View Post
TPO (thyroperoxidase) is an enzyme in the thyroid gland that is important to the production of thyroid hormones. TPO antibodies attack the process that creates the enzyme.

Tg (thyroglobulin) is a protein which carries T4/T3 in storage through the bloodstream until it's needed. Tg antibodies attack that protein.
Does that mean Tg antibodies deplete or interfere with the body using free T4/T3? I had somewhat elevated TG antibodies, but my TPO was still in range. Curious what those antibodies are actually doing...

 
Old 08-21-2008, 09:15 PM   #5
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Re: Antibodies - Tg and Tpo in Layman's Terms Please

Tg ABs cause hypothyroidism the same as TPO ABs. I'm unsure about the specific physiological mechanism by which that occurs.

 
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