katkatdd - I dont know what metformin is or does.
For my cortisol i'm taking 25mg of Cortate daily, half at breakfast and the other half around 11am-ish (depends when i'm on morning tea at work). My cortisol got nice and high, actually too high and i ended up with nausea, dizzyness and high blood pressure. Then i stopped taking it and i don't know why, maybe due to stress at the time, my cortisol dropped a lot. Now i'm back on it.
With my thyroid, my T4 doesn't appear to be the problem. I was only on Thyroxine for a short while. It's mostly my T3 which keeps dropping if i'm not on T3 meds, of which i'm on a natural one which is made by a chemist. It's called Triiodothyronine. Not sure what name it goes by in other countries and i've never heard it mentioned by a single poster on the boards ever.
Is the levo for your T4? If so, does your doctor ever check or recheck your Free T3? some doctors are solely fixated on the T4.
So now i'm on the Cortate, my T3 med, iron and Vitamin D supplements, iodine and selenium, a multi B daily. Also i was put on something called DIM to help lower my excess estrogen. I'm also on some naturopathic herbs to help with my menstrual cycles and estrogen excess. I think that's about it.
I had a saliva hormone panel done prior to being medicated with thyroid meds to see where ALL my hormones were at. My testosterone was high then as was my estrogen. About a year later we repeated the entire hormone panel saliva test and my testosterone had self correct and my estrogen was much better, but we're still looking at the estrogen.
When i began all this i thought it would simply be a matter of popping a pill a day and life would return to normal, but now i've realised where hormones are involved that it really can take some "tweeking" to get the entire hormonal and endocrine system running effectively. It helps to have a patient doctor who takes an interest. I guess i'm lucky that my doctor suffers from Hashimoto's too so he has an interest and isn't just doing it for the cash