If there is any one thing that can be taken as "fact" with this disease, it's that nothing should be written in stone. That includes the "right" way to take the medicine for it.
In the beginning, I took mine strictly by the book. In the a.m., on an empty stomach, with nothing but water for an hour after taking the pill. After I began feeling so much better that I felt it was safe to experiment, I began having coffee/non-dairy creamer within a half hour. It didn't make me feel any worse, so I stretched the rules again by having coffee immediately after med. Still no difference. I've been following this routine now for over 5 years, so see no reason to change because a new unofficial "study" says I shouldn't.
It was also my understanding in the beginning that calcium couldn't be taken with thyroid med, so I was devastated to think I could no longer eat my favorite breakfast - cereal with milk. One wise former member here informed me that as long as the same routine is followed almost daily, that I could indeed have cereal w milk if I chose. So, I still have cereal/milk nearly every day. No problem there. (I do, however, separate the med and my calcium supplement tablets far apart. Don't want to go too
wild and crazy bending the rules.
As for taking the med at night... For levothyroxine users, it might (or might not) be ok. But natural dessicated hormone users would risk some sleepless nights, because the T3 could theoretically ramp them up for 12 hours after taking the med. And that could leave them flat exhausted during their daytime hours - both from the lack of sleep and the lack of a T3 supply that has been used up already. I would never be able to take either kind at night, because I snack after dinner, leaving food in my stomach when I go to bed.
There are almost as many options for taking med as there are hypothyroid folks. If one method doesn't work, others can be tried. Nothing about hypothyroidism should be written in stone.