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Old 04-21-2002, 10:09 AM   #1
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Does Antibiotics make thyroid symptoms worse?

Hello...I am new to this forum and I'm hoping to find some help or at least hope for my problem. I was diagnosed with Hashimotos three years ago, I also have Lyme disease and I'm being treated with antibiotic therapy. I am not on thyroid medication because I flucuate too much going from hyper to hypo. My symptoms seem worse with palpations, chest pain, nervousness, hypoglycemia, muscle aches etc. since I've been on antibiotics. Does antibiotics effect the thyroid in this way??? I was told it could be the Lyme disease because as the antibiotic begins to work you supposedly do feel worse, but I read JWALZ experience when she had strep throat and was on antibiotics, the symptoms sounded exactly like mine...it is difficult to know just what is happening...any advice...sure would appreciate it. Twinsister

 
Old 04-21-2002, 12:27 PM   #2
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Re: Does Antibiotics make thyroid symptoms worse?

Some antibiotics such as Rifampin and Rifabutin can induce hepatic metabolism of thyroid hormons and decrease level of thyroxin in your blood.

More than 99% of T4 and T3 circulate bound to several binding proteins, including thyroid binding globulin, prealbumin, and albumin. Many antibiotics circulate in blood bound to the same carrier proteins and can increase levels of free (unbound) thyroid hormones by replacing them. For example, in blood serum, Amoxicillin is approximately 20% protein-bound, Bactrim is approximately 57% bound (44% of trimethoprim and 70% of sulfamethoxazole are bound), Augmentin and Erythromycin are also highly protein-bound.

 
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Old 04-21-2002, 12:42 PM   #3
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Re: Does Antibiotics make thyroid symptoms worse?

Dear Bird123,
I am very interested in learning more about antibiotics and the thyroid. I just read your response but am kind of confused as to what that means exactly. I was feeling pretty good and my thyroid (I have Hashimoto's) was at a good level for me prior to getting strep throat and an upper respiratory illness. I received an injection of penicillin for the strep and a 10 day supply of Biacin for the upper respiratory illness. After that I have had symptoms of being hyper thyroid, severe hypoglycemia (which I've battled off and on for years),and just haven't felt right since. I did back off of my Synthroid for 4 days now and my chest pains have subsided but am still having the other symptoms. I have read that Adrenals can crash when you are really sick, especially if they are weak to start with. But I'm still not clear on the antibiotics and how they work on the thyroid. Could you go over that again for me as I would be so thankful. I'm just looking for answers as the doctor's don't seem to have any. Thanks so much. Jan

 
Old 04-21-2002, 09:05 PM   #4
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Re: Does Antibiotics make thyroid symptoms worse?

JWalz,
It sounds like we're on the right track with our concern of antibiotics but I'm with you on how to decifer what BIRD123 has said. BIRD123 are you in the medical field? You sure sound very informed...would love to have you explain for us. Twinsister
Thanks for your response Jwalz and Bird123!!

 
Old 04-21-2002, 09:32 PM   #5
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Re: Does Antibiotics make thyroid symptoms worse?

Hi Jan...I'm with you...Bird123 I'm a little confused as to what you explained to us...are you in the medical field or are you just blessed with this intelligence? I can sure tell I'm not on thyroid medication and I'm sure I need them as my mind sure doesn't seem to pick up or remember things so we could use some help in understanding your wonderful response BIRD123. I take it that the antibiotics certainly could play havoc with our thyroids...and by the way I am taking minocycline and will probably be on it for a couple more months...your response is greatly appreciated!!! Twinsister

 
Old 04-21-2002, 10:23 PM   #6
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Re: Does Antibiotics make thyroid symptoms worse?

It means that thyroid hormone assimilation may be reduced by antibiotics.

But a short course of antibiotics may not be significant to the thyroid level, at all.
I would not be concerned about it.

 
Old 04-22-2002, 12:17 AM   #7
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Re: Does Antibiotics make thyroid symptoms worse?

<BLOCKQUOTE><font size="1" face="Verdana, Arial">quote:</font><HR><B>...are you in the medical field or are you just blessed with this intelligence? </B><HR></BLOCKQUOTE>

I am not so intellegent, just work in medical field <IMG SRC="http://www.healthboards.com/ubb/smile.gif">
After release from the thyroid gland both T4 and T3 are bound to the transport proteins in the blood. So does Synthroid, a synthetic T4. Approximately 99% of the circulating thyroid hormones are bound to the blood proteins. Only 1% of thyroid hormones is unbound. Only unbound thyroid hormones are biologically active. The protein bound hormons are inactive. Most of the thyroid hormones are bound to the thyroid-binding globulin (TBG), a special carrier protein for T3/T4. A smaller fraction of the thyroid hormones is bound to different blood proteins, such as prealbumin and albumin. Many antibiotics are also bounded (attached) to albumin and other transport proteins in the blood. Therefore, antibiotics compete with thyroid hormones for the same transport proteins (i.e. albumin). When antibiotics get into the blood, some amount of the thyroid hormons (or Synthroid) may detach from the albumin and become biologically active, causing hyperthyroid symptoms. So, the more antibiotic binds to the serum proteins, the more thyroid hormons may become unbound and active. It is true not only with antibiotics. For example, Aspirin also competes with T3/T4 for transport proteins, and therefore increase the free hormone levels. Tylenol does not.

PDR does say anything about protein-binding properties of minocycline. It means it either doesn't bind to the proteins, or protein-binding properties have not been investigated yet. I am not sure what Biacin is. Biaxin has low protein binding. Approximately 60% of Penicillin is bound to serum protein.

 
Old 04-22-2002, 12:29 PM   #8
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Re: Does Antibiotics make thyroid symptoms worse?

Bird123...what a wonderful explanation. Thank you very much! This explains also why I have a difficult time with asprin yet I don't seem to have a problem with Tylenol.
Tree Frog...thank you too, but it difficult not to worry when your whole body is in turmoil, hyper symptoms are very difficult to deal with.
Twinsister

 
Old 04-22-2002, 12:49 PM   #9
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Re: Does Antibiotics make thyroid symptoms worse?

I just got over pneumonia a week ago. I was on a course of levaquin and zithromax 500mg. My thyroid levels came back tsh &lt;0.01 free t4 1.3 (0.58-1.64) my doc wanted to lower my 88mcg of synthoid. So my labs could be high because while i was on the antibiotics they may have moved more thryoid hormone into the active or free mode??? making my numbers a little elevated??? Is that what I am interpreting?? I am a RN but work as a pharmaceutical rep. I would never claim to be excessively smart but have a good understanding of stuff. What do you think of my levels while being on the antibiotics??

 
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