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Old 03-09-2011, 08:43 PM   #1
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High TPO - safe to get pregnant?

hi all,

i am diagnosed hyperthyroid and just started carbimazole.
My TPO reading is high 42.4 IU/ml (positive > 12).

Is it safe to conceive with high TPO? Will treatment affect TPO level? Will the TPO reading ever come down?

Thanks all.

Last edited by hyper M; 03-09-2011 at 10:47 PM.

 
Old 03-09-2011, 10:41 PM   #2
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Re: High TPO - safe to get pregnant?

Are you sure that's the right reference range? It looks like a TSH range, not TPO.

That titer of TPOs probably would not seriously affect pregnancy, but you should think hard about attempting it before your thyroid levels are stabilized. I'm not familiar enough with ATDs to be sure about the carbimazole being safe to take during pregnancy. You need to check that, too.

 
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Old 03-09-2011, 10:49 PM   #3
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Re: High TPO - safe to get pregnant?

Midwest, thanks for pointing out the error .. i have edited the range

would you know what levels of TPO would affect pregnancy?

Last edited by hyper M; 03-09-2011 at 11:08 PM.

 
Old 03-10-2011, 09:01 AM   #4
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Re: High TPO - safe to get pregnant?

No, I'm sorry. I've never seen any studies that have shown that. My presumption is that a number in the high hundreds or thousands would be most detrimental. Yours isn't so bad, really.
Uncontrolled hyperthyroidism would be much riskier than a low titer of TPOs.

 
Old 03-10-2011, 09:28 AM   #5
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Re: High TPO - safe to get pregnant?

It may be that it's actually not the TPOAbs that cause fertility issues. Just recently read about this - too bad it's not widely recognized (my sister who also has HypoT has been trying to get pregnant through IVF for quite some time now and her "fertility provider" obviously does not recognize the possibility or the fact that something could be done about it )

"We have reported on the fact (1998, American Journal of Reproductive Immunology) that approximately 50% of women with TAI (regardless of the absence or presence of clinical hypothyroidism) have increased activated Natural Killer cell activity (NKa+) in their blood and that they are the ones that most commonly have reproductive failure.

We also showed that in such cases, aside from the need (in those with hypothyroidism) to adequately supplement with thyroid hormone replacement, the administration of intravenous gamma globulin (IVIG) or intralipid (IL) therapy in combination with steroids such as dexamethasone or prednisone (starting at least 4-7 days prior to ovulation or egg retrieval) markedly improves IVF birth rates."


(The percentage of NK cells in blood in normal healthy individuals varies from 5% to 29%.)

Last edited by FinnMaid; 03-10-2011 at 09:48 AM. Reason: Added info

 
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